 Micro-needles, MNs, have become increasingly popular in biomedical applications due to their ability to deliver drugs and biomarkers into the body without causing pain or discomfort. They are also being used in combination with microfluidic devices to create lab on a chip and organ on a chip systems. These systems offer the potential to monitor biomarkers in real time, making them highly desirable tools for medical research. This article was authored by Renata Maya, Violeta Carvalho, Roy Lima, and others.