 This study assessed the levels of health literacy and its socio-demographic determinants among undergraduate students of Tribhuvan University, Nepal. The results showed that nearly two-thirds of the students had limited health literacy, with female students, students from non-health-related majors, students with unsatisfactory health status, students with poor financial status, and students with low self-esteem being more likely to have limited health literacy. These findings suggest that university students should not be assumed to be health literate and interventions to improve students' health literacy, especially for those whose majors are not health-related, should be implemented. Further studies using a longer version of the health literacy survey questionnaire and qualitative methods to explore more on determinants of health literacy are recommended. This article was authored by Sandesh Buzil, Rajan Pautil, Malan Gair, and others.