Animated Abstract: Eduardo Tolosa & colleagues (EMBO Mol. Med.)

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Published on Oct 28, 2015

This is the first proof-of-principle that induced pluripotent stem cell (iPSC)-derived dopaminergic neurons (DAn) from sporadic and monogenetic Parkinson's disease (PD) patients show the same epigenomic changes as compared to healthy controls.

Original article: http://embomolmed.embopress.org/looku...
EMBO Molecular Medicine

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients

Rubén Fernández-Santiago, Iria Carballo-Carbajal, Giancarlo Castellano, Roger Torrent, Yvonne Richaud, Adriana Sánchez-Danés, Roser Vilarrasa-Blasi, Alex Sánchez-Pla, José Luis Mosquera, Jordi Soriano, José López-Barneo, Josep M. Canals, Jordi Alberch, Ángel Raya, Miquel Vila, Antonella Consiglio, José I. Martín-Subero, Mario Ezquerra & Eduardo Tolosa

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