 This study found that elevated TNXB expression in glioma tissues correlated with tumor grade, according to several databases. Univariate and multivariate Cox regression indicated that TNXB was an independent indicator of glioma prognosis. Pathway enrichment analyses suggested that TNXB participates in the immune response, humoral immune response and interferon gamma mediated signaling pathways. Furthermore, TNXB expression was significantly associated with higher levels of tumor infiltrating immune cells in diverse cancers. Additionally, TNXB expression was strongly associated with genetic markers of immune cells and common immune checkpoint molecules, PD1, PDL1, CTLA4, TIM3, LAG3, PDCD1, LG2, TIDGET and Cyclic15. These findings suggest that TNXB expression may be a useful prognostic marker for glioma patients and may play an immunomodulatory role in tumors. This article was authored by Kofumar, Awanchiu, Chenying Huang and others. We are article.tv, links in the description below.