 This study examined the time trends and prevalence of physical activity and sedentary behavior among adults of Brazilian capitals, between 2006 and 2021, including the pandemic period. The results show that leisure time physical activity increased significantly from 29% in 2009, to 39% in 2019, followed by a decrease of 2.3% between 2020 and 2021. Additionally, total screen time increased considerably between 2019 and 2020, 4.7%, and physical inactivity tended to reduce along the series, however, its prevalence increased by 3.4% between 2019 and 2021, as well as physical activity while commuting decreasing by 3.7%. Overall, these findings suggest that more strategies are needed to tackle physical inactivity and sedentary behavior, and to review the post-pandemic national targets. This article was authored by Thania Mara Teixeira-Rizend Faria, Alana Gomez-De Silva, Rafael Morera-Claro, and others. We are article.tv, links in the description below.