 This study investigates the role of mitochondrial dysfunction and immune responses in Alzheimer's disease, AD. It uses bioinformatic methods to identify differentially expressed genes, DEGs, and gene sets related to AD, and then analyzes the interaction between these genes and immune cell infiltration. The researchers find five hub mitodeGs that are highly associated with AD, and they also observe that these genes interact with immune cell infiltration. Additionally, the researchers show that one of these genes, OPA1, plays a key role in mitochondrial damage and neuronal apoptosis caused by amyloid beta-peptid, A142. This study provides valuable insights into the potential pathogenesis of AD and suggests new targets for therapeutic intervention. This article was authored by Yao Danjong, Yu Yangmiao, Jin Tan, and others.