 Heparin, a commonly used anticoagulant, has been found to have anti-inflammatory properties. This systematic review aimed to evaluate the efficacy and safety of heparin and its derivatives as anti-inflammatory agents. Studies were identified through searches of PubMed, Scopus, Web of Science, Ovid, Elzeva, and Google Scholar. Randomized controlled trials, RCTs, and trials with quasi-experimental designs were included if they were conducted in a clinical setting and published in English. At the 280 studies identified, 57 met the inclusion criteria. Most of these studies involved asthma, inflammatory bowel disease, cardiopulmonary bypass, or cataract surgery. Overall, 65% of the studies scored 3 or higher on the JEDAD scale, while 12 studies scored above 40% on the consult checklist. 40 studies used unfractionated heparin, UFH, for interventions, while the remaining studies used low molecular weight heparin, LNWH. Despite some conflicting results, heparin appears to be A. This article was authored by Sarah Musavi, Mandana Muradi, Tina Korshidhamad, and others. We are article.tv, links in the description below.