 Endophytes are microorganisms that live inside the cells of plants without causing any harm. They can provide protection against disease, causing organisms and help plants tolerate environmental stressors. Studies have shown that endophytes produce a variety of bioactive compounds that can be used to treat various diseases in humans. These compounds include phenolic acids, alkaloids, chenoneses, steroids, saponins, tannins, and terpenoids. Additionally, endophytes can also act as a source of potential drugs due to their ability to produce these bioactive compounds. This article was authored by I.M.I.D. Emmanuel Fadigi and Alubiukola Aluranti-Babalola.