 Primary coutaneous musinus carcinoma, PCMC, is a rare form of skin cancer characteristic by slow growth and solitary lesions. It has been found to have a distinctive molecular profile, including a decrease in the expression of the epigenetic marker H3K27-M3. This suggests that epigenetics may play a role in the development of this type of cancer. This article was authored by Shuhau Lee, Chen Chun Q, and Chen Chen Cheng.