 The study examined the effects of ionic strength on the aggregation of alpha-synocline syn, which is associated with Parkinson's disease. At mildly acidic pH 5.5, the rate of syn aggregation decreased when the ionic strength increased. This suggests that short-range attractive electrostatic interactions are important for secondary nucleation as well as heterogeneous primary nucleation. These interactions were also confirmed in Monte Carlo simulations of synmonomers interacting with surface-crafted C-terminal tails and found to be weakened in the presence of salt. Therefore, the screening of the long-range repulsion between negatively charged monomers and negative surfaces outweighed the attractive electrostatic component resulting in a decrease in the rate of syn aggregation. This article was authored by Ricardo Gasper, Mikhail Lund, Emma Spa, and others.