 This study demonstrated the potential of using mRNA medicines to deliver therapeutic factors, such as transcription factors, into target sites. Specifically, it showed that the combination of VEGF and RUNC's two mRNAs can induce enhanced bone regeneration through both osteogenic and angiogenic mechanisms. Furthermore, the mRNAs were found to increase vessel formation and promote rapid bone formation. This article was offered by Marui Jong, Yuta Fukushima, Kosep Nozaki, and others.