 Hi, I am Dr. Yogesh Singh, I work as a consultant dermatologist at Manipal Hospital, Bangalore. Lupus is a difficult disease to diagnose. Unlike other diseases, there is no single lab test that can diagnose lupus. For example, in diabetes, if the sugar levels are below or above a certain level, then a diagnosis of diabetes can be made. A diagnosis of lupus is based on signs and symptoms. Detection of certain antibodies in the blood can support the diagnosis. Most patients with lupus have positive ANA or anti-nuclear antibodies.