 The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered exosomes or exosemometics, which may be artificial, liposomal, or cell-derived vesicles as advanced platforms for targeted drug delivery. Here, we provide the current state of the art of using exosome or exosome inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally, the challenges which have been identified to date in this field are summarized. This article was authored by Sofia G. Antemigiaris, Spiridon Murtiz, and Antonia Marezioti.