 Metal oxide nanoparticles are gaining increasing interest due to their potential use as antibacterial agents. Metal oxide nanoparticles composed of multiple metals offer unique advantages over single metal oxide nanoparticles, such as increased antibacterial efficacy and reduced cytotoxicity. Additionally, polymetallic oxide nanoparticles can combine the best features of each individual metal oxide, resulting in enhanced antibacterial activity and decreased cytotoxicity. This article was authored by Slava Kostankic, Sneha Suman, Francia Huck, and others.