 Morning everyone! Many of you know the globe health network really well, some of you will be new too. We have a couple of new programmes that I really want to tell you about including the diploma. I think next year we have to need a whole section for the diploma. But the big news since we spoke last is the global health network is now a WHO Collaborating Centre which I'll talk more about which is super exciting. There's a few in Oxford but we're a torn approaches centre for the Science Division ond rhan, ar gyfer allan gyda'r busch a fyddwch fan hyffordd. Ac rydym wedi bod wych yn ei ddweud drws wrth yr hyn. Mae'r pethau dyw, mae'r ddweud am erinu. Ond fe wnaeth fydd yn gweithio mewn cyfwyrol am gweithio i whyffodd a'r adnodol yn ddweud y dyma i ddweud y llaw fwyaf ac yn ddechrau'r blaen yw hynny, ac mae'n gweithio i wneud i weithio gyda'r bethau gwaith bod y dyma yw lle yn dystod o'r adnodd oedd, that setting and often adapt the really like seemingly scary and off putting things like federated analysis and make it really practical and applicable in many different settings. You know, we all know that we're all working to try and address the gap in research equity and I know there's a whole session on equity later and I'll talk about our diploma which we hope is making some inroads on that. But basically all the Globe Health Network does is move knowledge, is move information, and we do that in person and online. We had this sort of underpinning talent as well that every disease needs to have every type of research happen and we're doing a lot of work this week which I'll talk about in a minute with the World Health Organization and the WHA resolution on clinical trials which is excellent, but clinical trials don't happen in isolation in it to run a study a clinical trial anywhere you need epidemiology to understand burden of disease, you need social science to really understand the context and obviously everything from diagnosis to just what we can do. yn ymddarnol, mwyaf, a'r hyn o'r ffordd, rydych yn ymweld i'w rhaglen yma. Mae'n ddych chi'n mynd i ddim yn bwysig i ffwll addysgu'r bwysig, a'n ddych chi'n ddweud allu ffwrdd yng ngyfafodol, a fyddwn ni'n gofyniaeth bod hwn yn ddifoedd, a'r ffwrdd yma'n gweithio'n ddweud yn ddengu, yn nifer o'r Llyfrgellol o Leishman i ASYs yn afrygu. Mae'n gweithio'n ddweudio i'n mynd i ddim yn gweithio'r arddangos ac mae'r rhan o'r cyhoeddwyr yn gweithio ar y yw'r gweithio. Mae'r gweithio ar y dyfodol o'r cyhoeddwyr ar gyhoeddwyr. Mae'r gweithio'r gweithio ar y gweithio adder yng Nghaerlygu a'r Gweithredu yn ei ddweud i'r meddwl er mwyn rhanol, ac mae'n defnyddio, mae'n ddau i gysylltiadau yng Nghaerlygu. Mae'n rhan o'r gweithio i'r gweithio'r systemu yn ei ddweud, ac mae'n rhan o'r gweithio'r systemu yn ei ddweud i gyd wedi bod hynny, ac mae'r grwp ychydig i gwaith yma, gwaith o'r grwp ffordd yng Ngolod Gweithloed, yn cymdeithasio'r ffordd ar gweithio'r ffordd. Rwy'n gwneud o'r grwp ffordd mewn gwirionedd, rwy'n gweithio'r ymgynghwylliant, ac rydyn ni'n gweithio'n cynnigodau a mecanismu o'r grwp yn gweithio'r ffordd. Rydyn ni'n gymhwylliant ar y platform, ac y gallwn ddwy'r idea yn gweithio'r gwaith y gwrthoedd i'r grwp yn ddechrau, dau'r ddarparu diwrnod, busd yn ddigwydd, diwrnod o gylwyd. Byddwch, beth eu defnyddio'r rheswm agliadau i wych. Pe bachon gael ac yn ddod o ddwylo cymaint o rhanedd – a wnaeth eich peidio a phobl injusticell ei bob bwysig yn cyflin o bwysig. Yn dweud allan gwaith o'r gyfer yw'r hynny i fi fod yn dweud'r hynny yma, yn ei wasgen ei ddod o'r gydigfyrdd. Mae'r prif mwyaf os yw eisiau yn ddweud i'n ddysgu'r rhanedd o feith o'u o'r ystafell o'r ysgol o'r Pwro o'r Prif yn ysgrifennu'r ystafell o'r ystafell sydd ystafell o'r ystafell o'r cyfnod yn gwylliant, oherwydd y gallwn cyfnod oes yn Oxford o'r Ysgrifennu o'r Eirwyddoedd Cymru i'r welganig yn Gylliddoedd. A dyma'r ysgrifennu'n golygu, yna yw ymddych i'r bwysig i'r cyflodd y gallwn ysgrifennu i gyfan y gyd-onai'r gweithio yn ysgrifennu i'r bwysig. Felly dyna'n dweud ar y cyffredinol 15 yma. Mike, rydyn ni'n gyffredinol i'r Gymru? Felly dyna'n gweithio i'r Gwylodau Ievan i'r rhan, yn gyffredinol i'r Gymru, ac mae'n gweithio i'r cyffredinol i'r sefydliadau i'r problemau. Mae'r cyffredinol yn ymgyrchafroedd yng nghyrch yn gweithio i'r Gwylodau Ievan i'r Cyffredinol. Mae'r cyffredinol yn ymgyrchafr hwnnw, idea. We're just trying to create access to protocols and SOPs and things, but over the years it's grown and we now have 60 different interconnected communities of practice. Adam, who I did see somewhere, looks after these communities and we have all these different types of topics, disease areas and crosscutting themes like community engagement, social science, but also disease topics too. And so those are run by organisations like WHO, CEPI, many of the big NIH funding groups say, and so they all have their own particular topic within the wider topic of global health research. And so those groups are all using the global health network as their mechanism for sharing their knowledge and information and working with their teams. But the real exciting piece is we have literally hundreds of thousands of research workers, lab staff, community health workers, nurses, doctors, policy makers who come in their thousands to access those tools and resources. And that's why I keep saying all we're doing really is mobilising knowledge in between the two. And we do a lot of work with the WHO across different areas and that's what's really helped us bring this together in this really large connected platform. We've done a lot of thinking on the last few years about the governance and structure because it's great sitting in Oxford being an Oxford entity. And that's very important for sometimes for students they like to have that Oxford clarity or external partners as well. But we're all working really hard to take Oxford out more and have that more equitable approach. And really for the global health network we don't want it to be a kind of Oxford thing. And so we've set this up as a global franchise and we have collaborating centres in Africa, Asia, Latin America and soon adding MENA, aren't we, Sylvia, which is very exciting. So the Middle East and North Africa region, really for the Arabic speaking nations. So funding can go directly to all of these partners now. And our recent award we've just got from Welcome. We've got six partners, seven partners across Latin America. And the grant is going literally there's no lead PI and there's no lead institution. It's proper teen science. And that grant will be going equally across all of those institutions. And many of our partners will apply for a grant as the global health network Ghana or Malaysia or wherever they're going to be. Certainly the MENA region is taking this approach and the funding can go directly to them. And we are representing the global operations team, but even we're not solely based in Oxford anymore and we have colleagues around the globe. And it really does work well on this really trying to create this equity into where research funding goes. So just as an example, this is what's happening in Africa. We work with Africa CDC and AMREF. We've got MOUs with all these different organisations and all the dots are individuals. And these are colleagues that are employed as the global health network coordinator for different topics. So we work with IDRC, for example, and they were running a programme on AI with them. We have four coordinators across Africa who are working to connect up and do capacity building in AI, in healthcare. And that is the model that we roll for all those different topics. And that means we can have this really nice footprint on the ground where we can deliver things like research cards and workshops in the workplace. And any of those teams that we have employed under that particular role can also turn their hand to any of the other topics we want to deliver. And this is the same across the other regions too. So people come because they want to find these training courses. We've got professional development scheme, many of you know about already. And all of these largely now are driven by our partners who contribute the content onto the training. But this could also be delivered in person across that regional network that we've just described. The idea is that it's like a journey to impact. So nobody really comes to the global network once and just does a GCP course. But we build this relationship with our community over many years, literally many years now. And the idea is that they can come and find a piece of training. They might connect up with others. They might form a working group and run a particular study. They might come back and do a workshop. And it's this really sequential learning over time. And we divide everything up around this sort of core set of skills that we want to impart and apply that to whatever disease is appropriate. So this graph really shows how that can happen for any one individual, but it could also happen for a team or even a whole programme. And it's a long term, slow but really building set of experience. So a lab in Ghana, for example, has worked with us for many years and they have all of their nice certificates in their labs training teams. But they means that they can attract funding from outside partners and workers research centres for other groups. But they've been using this all to also apply for grants or to find another assay with another colleague. And then when COVID came along, we connected up with lots of groups to work with other programmes so they could run the disease characterization protocols. So it's all this sort of long term connecting up that's really, really impactful over time. I just quickly want to mention this new initiative we've got because it might be something that many of you could take on and think about whether it would be a useful thing in your work. So we work with the WHO 75 year anniversary and they wanted to have leadership challenges. So we were thinking about how we could use this with lots of the work we do. And we came up with trying to work with nurses, midwives, allied health workers, community health workers. You know, that workforce at the front line that really can be taking up a leadership role in research, but are often kind of at the bottom of the pyramid and often don't get that opportunity. So they do research and then they don't really have the opportunity to really be recognised for that or step up. And so the thousand challenges can be launched later this month, hopefully, and will be a system that will take teams through that process. It helps you set the question, work out what they're going to measure and then catch the data, report it and take those findings up into practice. So if they're going to take a step of the way, they're offered help and support, either with resources we have already or we're also set up support groups for each of these studies. So each of those steps they need. So they might need different people over the course of time. They might need help setting up RedCap or they might need help going to their employers and asking, you know, even permission to do the studies. I think examples we've been talking to groups in Nepal who wants to go into the community and look at some mental health processes they've been doing for a long time. Maybe they're running support groups or mentoring schemes in the community, but they don't know it works and they've never measured it. So it's a really straightforward practical piece of work where we can assess whether or not it's having an impact on the community and work with them to work out what they measure to show whether that works or not. So there's just, you know, there's 100 million ideas of things that could be applied to this. And the point is, it's just a support system that takes them through the process of running a good study but makes it visible. It's under the thousand challenge banner. It's a WHO initiative. We're trying to say Tedros to give the Tedros prize for various elements of it. Thank you, SAS for the idea on prizes. Another example is our colleague Maurevoir in Calife who's done a really nice piece of work over many years with colleagues on the ward there. And she described this to us as an audit, which it could be described as an audit, but it was a really nice high quality piece of work that changed the practice on the ward. So that's a great example of a thousand challenge that we're going to use this actually as an example to test the system. I just quickly want to explain one of the latest sort of innovations that we're able to do with the global health network, which is to be a research platform in its own right. So this is a piece of work we've just done with welcome. So I can't share these slides, but I'm happy to just show the sort of big, big sort of headline outcome. Welcome on to just to work with them rather than run a meeting in the Euston Road to say where should we be funding our infection disease grants. And so they work with us. We run this nice process, it's like a kind of crowd delphi. We had 3,700 respondents from across the global south and the questions were really clear. What infectious diseases do you think are the highest threat of escalation? What sort of research should be being done and what are the barriers to doing that research? The big message was that we've got the arborviruses and the really vector-borne diseases off the scale when we grouped us together as seen as the biggest threat in the global south compared to the most respiratory infections in the global north and a very different picture depending where you are in the world and actually quite a different picture than many of the funders are actually wanting to fund. So we were delighted with these results for my colleagues for the Africa, you know, still keeping malaria obviously on the dashboard there. And the driver for that when we looked into the data which we pushed into, we took this to workshops. So we did a big survey and then we did three workshops around the globe and said why, you know, tell us the context. It was climate change and the movement of vectors. So not necessarily a surprise but a very strong body of robust evidence to explain that. And so this is how it looks when you look at the difference between the high and low income countries. So this is a draft report at the moment so I just wanted to share it to you because it's quite interesting. I'll just click forward a bit on this but this is, we've also just repeated this methodology for the WHO. We've just been presented today by Vassie and I think Jeremy at PAHO meeting. This isn't their slide but the nice thing is you can almost overlay it because the work we've just done with WHO was to ask about the WHO trials resolution that's gone out and WHO are trying to implement it and we've done a piece of research then to ask what the barriers are and what the perceptions are about implementing the WHO trials resolution and we almost had exact same picture come through. A similar number of respondents, a different audience but they were all saying that with agreement about institutional support but obviously research training because that's what we do. The institutional report, community engagement, access to funding but really working in communities and networks is really vital so we're very pleased to get this evidence. Just to finish off, this is really exciting, it's a great week to be presenting this. We have our first cohort of students this week, Oxford's first entirely distant qualification. It took seven years to get it through the system in Oxford and our target audience are people that are already working in research in the workplace but for social, economic, whatever reasons they can't come to Oxford and so this is all about creating equity and who can access an Oxford qualification and so this course is based on the essential curricula which was the diagram I showed you right at the beginning which was a study from the same methodology I just described and that's where we set out the essential curricula for health research so this diploma will take students through this whole set of learnings and hopefully equip them to really design and lead and run their own studies and we really appreciate the support of Afox as well, having some scholars through for this and we may even think about taking this up into the masters and also following with other similar courses with this online approach. It hasn't been easy because it's Oxford's first so you can imagine but we're really proud and really excited. We're also quite keen if anybody's interested in doing some teaching or helping with exam boards, tutors, it's a really nice one to get involved with. It's not a huge workload and we really want to involve lots of people and also students for next year just selling that out there. So this is really what we do to try and really create some of that equity and hopefully this sort of workplace ethos is really impacting some of the sustainable development goals.