 This study investigated the expression of microRNA-16, MIR-16, surviving, and tumor protein P53-regulated apoptosis-inducing protein 1, TP53-AIPI, TP53, in preclamptic and normotensive pregnancies and checked for any correlation between MIR-16 and mRNA expression of surviving in TP53. The results showed that MIR-16 expression was significantly increased in preclamptic pregnancies compared to normotensive pregnancies. Additionally, the mRNA expression levels of surviving in TP53 were found to be deregulated in preeclampsia with decreased surviving and increased TP53. Furthermore, MIR-16 expression was found to correlate negatively with surviving expression while showing a positive correlation with TP53 expression. These findings suggest that MIR-16 may play a role in the pathophysiology of preeclampsia through its effects on apoptosis-related genes such as surviving and TP53. This article was authored by Zima Ali, Azma Zuffer, Zima Zaki, and others.