 The health stigma and discrimination framework is a global, cross-cutting framework that focuses on theory, research, and practice to guide intervention development, measurement, research, and policy for reducing health-related stigma and improving health outcomes across various health conditions, including leprosy, epilepsy, mental health, cancer, HIV, and obesity overweight. The framework also examines how stigma related to race, gender, sexual orientation, class, and occupation intersects with health-related stigmas and can be used to enhance research, programming, and policy efforts. This article was offered by an L. Stangle, Valerie A. Earnshaw, Carmen H. Logee, and others.