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Published on Oct 4, 2010
Part 1 of 2 of "Multicentric Reticulohistiocytosis" - Mystery Diagnosis (Uncut Version). First broadcast on the Discovery Health Channel on August 16, 2010
This Mystery Diagnosis episode is about Multicentric Reticulohistiocytosis . Mystery Diagnosis is a wonderful program on the Discovery Health channel - new episodes are shown on Monday nights at 10PM EST, but you can catch many older episodes during the week at various times.... and they sometimes pop up on Discovery and TLC.
What is Multicentric Reticulohistiocytosis? Written by Pamela Donner
Multicentric Reticulohistiocytosis (MR, MRH, previously also called Lipoid dermatoarthritis) is a rare disease, primarily affecting patients in their adulthood characterized by the rapid appearance of multiple papules and nodules arising in conjunction with severe arthritis. The name was first proposed in 1954 by Goltz and Laymon. MRH is very rare. The average dermatologist, rheumatologist, or orthopedist will see at most 1-2 cases in an entire career. MRH may become inactive after several years, often after about 8 years. In about 28% of cases, the disease appears to be related to an underlying malignancy. MRH precedes the development of cancer in 73% of cases. No therapy consistently improves MRH. The response to therapy is difficult to determine because of the rarity of the disease and the lack of controlled studies.