 Translational science is a rapidly evolving field that requires quality and efficiency to be prioritized in order to ensure optimal outcomes. During the Covid-19 pandemic, the Clinical and Translational Science Award, CTSA, consortium was able to identify key areas of strength and weaknesses related to quality and efficiency. This environmental scan revealed that CTSA institutions have strong adaptive capacity and are prepared to respond to emerging challenges. Institutions must continue to focus on quality and efficiency to ensure successful translation of scientific discoveries into clinical practice. This article was authored by Raj Seesha, Veronica Hoyo, Patricia Musach, and others.