 In this study, researchers used a nanoarchitectonic approach to create biohybrid materials that contain living cells. They tested two different types of materials, bionanocomposites made from chitosan and alginate, which are both combined with Cp-like clay minerals and shaped into films, beads, or foams, and silica-based matrices with low sodium content created through sol-gel methods and pre-synthesized yoke-shell bionanohybrids. The results showed that the silica-based matrices provided better protection against cell death than the other materials, while still allowing the cells to remain active and producing ethanol. This suggests that the silica-based matrices may be more suitable for long-term applications such as implants or medical devices. This article was authored by Celia Martin Morales, Jorge Fernandez-Mendes, Pilar Aranda, and others.