 A novel Ciprofloxacin-loaded Kytosan nanoparticles coding system onto titanium surface has been developed and characterized, which exhibits antibiotic release capability and inhibits the in vitro growth of Staphylococcus aureus and Pseudomonas aerobinosa. Preliminary biocompatibility data have also been discussed, making it a promising candidate for preventing titanium implant-associated infections. This article was authored by Elvira de Giglio, Adriana Trapani, Damiana Caffagna, and others.