 This study investigates the use of locally delivered antibiotic impregnated nanohydroxyapatite, NHATB, beads for treating chronic osteomyelitis. The results showed that the success rate was approximately 98% with no reinfections reported. Additionally, the quality of life of all patients improved significantly over time. Furthermore, systemic exposure to vancomycin and gentamycin was limited while high local antibiotics concentrations were detected in wound drainage fluid. No nephrotoxicity or hepatotoxicity was observed and most adverse events were resolved without removing the beads. Overall, these findings suggest that NHATB beads are a promising option for localized antibiotic delivery in chronic osteomyelitis treatment. This article was authored by Chitawee Jayamton, Adinan Apavakarun, Sari Anuramwat and others.