 Plasma treatment can alter the surface characteristics of polymers, such as changing their wetability and adhesiveness. However, little research has been done on how plasma affects polymers at different scales or its potential use in antifouling applications. In this study, it was found that plasma-activated PDMS nanopillars were able to drastically reduce bacterial adhesion when compared to untreated planar surfaces. This effect was even stronger when the pillars were reduced in size, suggesting that the plasma activation process may be enhanced by confining the material to smaller dimensions. These results suggest that plasma activation could be used to create non-fouling polymeric materials with improved antifouling properties. This article was authored by Naseem Mahmoudi, Dario G. Bazoli, Tim W. Overton, and others.