 This study aimed to assist the diagnostic accuracy of clinicians in distinguishing Pythium from Fungal keratitis. The results showed that clinicians had a low rate of success in identifying Pythium as the cause of keratitis, with only 56% of cases being correctly identified. Furthermore, there was no significant difference in the identification rates between consultants and trainees. The most common clinical features used to distinguish Pythium from Fungal keratitis included the presence of tentacles, peripheral guttering, dot-like infiltrates, and elevated plaques. This suggests that further education and training may be necessary to improve the diagnostic accuracy of clinicians when dealing with Pythium keratitis. This article was authored by Rakhi P. Deakras, Mohamed, and Suzata Das.