 Abstract stress granules, SGs, are non-enveloped structures formed from aggregations of proteins and RNAs under various stresses such as hypoxia, viral infections, oxidative, osmotic, and heat shock stress. These aggregates help cells cope with stress by reducing damage and promoting survival. Recent studies suggest that SGs play a role in tumoragesis and can be used as potential targets for cancer therapies. This article was offered by Hornju, Jingluo, Kalin Mao, and others.