 Abstract growing interest in extracellular vesicles, EVs, including exosomes and micro-vesicles, as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the pre-clinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best practice models for EV therapies. Stem Cells Translational Medicine 2017, 6 colon 1730-1739 This article was authored by Agnes T. Rayner, Kenneth W. Whitware, Bas W. M. van Borkum, and others.