 So I'd like to start off thanking the Brain Foundation for the generosity and supporting this research in stroke and continuing the theme of stroke. Stroke is a leading cause of disability in adults and a major cause of death worldwide. And in majority of cases it is caused by a sudden blockage in the arteries supplying oxygen to the brain and as a result brain cells quickly die within the matter of minutes. And therefore the current rationale of treatment is to quickly as soon as possible to reopen the artery to restore blood flow. However, not uncommonly, even after successful recanolisation or reopening the artery, many neurons that were still living at the time when blood flow was restored would still go on nonetheless to cell death and we do not completely understand why that is the case. And some neurons even go on to unpredictable and sometimes uncontrollable bleeding and swelling after recanolisation or restoring blood flow. And these events have a lot of outcome, highly impacts on the outcomes of the patients and patients do suffer a lot from these sequelae and complications. This research is focused on understanding these processes by using MRI to look at how brain cells respond to restoration of blood flow or reperfusion or recanolisation, especially asking why do some blood cells die, some survive and some bleed after restoring blood flow. And we'll be recruiting patients who have had a stroke to undergo a series of multimodal MRI scans over 12 months. We try to obtain a comprehensive neuroimaging profile studying the anatomy, the function, the metabolism as well as the human dynamics of the neurons as well as the surrounding blood vessels. At different stages of their injury, recovery and reorganisation. And we hope that by understanding the pathway physiology of these processes we can find ways to maximise the effectiveness of current treatment as well as find ways to see how we can develop new therapies perhaps to increase the resilience of brain cells when they are under stress from ischemia. And ultimately we want to help stroke patients reduce their disability and reduce the disease burden for them and their carers. Thank you.