 The Enhanced Detection System for Healthcare Associated Transmission, EDS had, uses whole genome sequencing, WGS, surveillance and machine learning of the electronic health record, EHR, to detect and investigate potential transmissions of infectious diseases in real time. This system has been successfully implemented at our institution and has already led to the identification of several small clusters of potentially interruptable transmission routes. Additionally, this system has reduced the turnaround time from patient culture date to IP notification to just 19 days, demonstrating its potential to reduce costs for hospitals, improve patient safety and save lives. This article was authored by Alexander Sunderman, Marisa Griffith, that's our Rangachar Srinivasa and others.