 In this study, researchers examined seven cerebrospinal fluid, CSF, and six plasma biomarkers in relation to beta amyloid, a better pet uptake to better understand the progression of Alzheimer's disease, AD. They found that a better levels change first, followed closely by levels of fast-related tau, p-tau, and total tau, t-tau. Neurograinin, YKL-40, and neurofilament light also increase after the point of a better pet positivity. These findings were replicated using the better, p-tau, and t-tau assays from five different manufacturers. Plasma biomarker levels had smaller dynamic ranges, with the exception of p-tau and t-tau, which were similar. Overall, these results suggest that the amyloid cascade hypothesis may be supported in humans. This article was authored by Sebastian Pankvist, Philippe Essinsel, Eric Stomruud, and others. We are article.tv, links in the description below.