 Cytokine storm is a condition caused by an overproduction of certain inflammatory cytokines, resulting in a hyper-inflammatory state that can lead to organ failure and death. This condition was first observed in patients undergoing bone marrow transplants, but it has since been linked to various other diseases, including sepsis, autoimmunity, and coronavirus disease 2019-COVID-19. In COVID-19 patients, elevated levels of certain cytokines, such as interleukin-1, IL-1, interferon-gamma, IFN-gamma, and tumor necrosis factor alpha, TNF-alpha, have been found, and these cytokines have been shown to correlate with disease severity. Several treatments have been developed to reduce the effects of cytokine storm, including corticosteroids, cytokine inhibitors, and other immunosuppressant drugs. These treatments have proven successful in treating critically ill patients, but more research is needed to develop effective treatments for less severe cases. This article was authored by Christian Zanza, Tatiana Romanskaya, Alice Karamanetti, and others.