 The study reports that transient receptor potential vanyloid 1, TRPV1, expressed in major sensory neuron subset controls severity and progression of experimental autoimmune encephalomyelitis, EAE, in mice, and likely in primary progressive MIS-TRPV1. These six congenics are protected from EAE due to reduced central nervous systems, CNS, infiltration, despite indistinguishable T-cell auto-reactivity and pathogenicity in the periphery of TRPV1, sufficient and deficient mice. The study identifies a predictor of severe disease course and a novel target for MS therapy. This article was authored by Jeffrey Paltzer, Shwe Jun Liu, Jason Yanfa, and others.