 Migraines are a debilitating condition characterized by severe headaches accompanied by nausea, sensitivity to light, and other symptoms. Recent research suggests that certain molecules may be involved in triggering migraines, including calcitonin gene-related peptid, CGRP. However, many people still experience migraines despite taking medications designed to block CGRP activity. In this review, we discussed several other potential targets for migraine treatment, such as nitric oxide, phosphodiesterase, 3 and minus 5, potassium channels, transient receptor potential, TRP, channels, and acid-sensing ion channels. These targets have been studied in animal models and humans, but no specific drugs have been developed yet. Nonetheless, these targets offer hope for developing new treatments for migraine sufferers who don't respond to current treatments. This article was authored by Linda Alhassani, Deirdre M. Boucheri, Hannah Creny, and others. We are article.tv, links in the description below.