 Okay, so let's get started. Welcome everyone. Like I actually don't know if I said my name yet, but I'm Jennifer Boyko. I'm the Manager of Scientific Operations with the Canadian Logitunals Study on Aging or CLSA for short. Thank you for joining us today for this webinar that is entitled Enhancing the CLSA Research Platform Updates on New Initiatives, Data Availability and Data Access. Before we get started, I'd like to acknowledge that the CLSA National Coordinating Centre and McMaster University are located on the traditional territories of the Mississauga and Haudenosaunee Nations and within the land protected by the Dish with One Spoon Wampum Agreement. And McGill University is on land which has long served as a site of meeting and exchange among Indigenous peoples including the Haudenosaunee and Anishinaabe Nations. We welcome and thank the diverse Indigenous peoples whose presence marks this territory, how much peoples of the world now gather. As attendees of this webinar, I encourage you to learn more and acknowledge the original inhabitants of the lands where we currently have the privilege to do our research, live and work, wherever that may be. Now on to the webinar for today, again entitled Enhancing the CLSA Research Platform Updates on New Initiatives, Data Availability and Data Access. We will have Dr. Praminder Raina and Dr. Matilda Saliva presenting the webinar. Dr. Raina is a professor in the Department of Health Research Methods, Evidence and Impact at McMaster University. He specializes in the epidemiology of aging with emphasis on developing the interdisciplinary field of neuroscience to understand the processes of aging from cell to society. Dr. Raina is a fellow at the Canadian, of the Canadian Academy of Health Sciences. He holds the Tier 1 Canada Research Chair in Giro Science and the Raymond and Margaret Labarge Chair in Research and Knowledge Application for Optimal Aging. He is the Scientific Director of the McMaster Institute for Research on Aging, as well as the and the Labarge Center for Mobility and Aging and is the lead principal investigator of the CLSA that we'll be talking about today. Dr. Matilda Saliva is the CLSA Data Access Officer. She coordinates the feasibility review of data and sample access applications with the CLSA, the release of data sets to approved users, communication of data release updates and responses to access queries from approved users and potential data applicants. She ensures providing Canadian and international research community with up-to-date information on the availability use and access of CLSA data. She has over 15 years experience in coordinating health research projects and prior to joining the CLSA, she worked as the National Access Coordinator for the Canadian Partnership for Tomorrow's Project and Data Harmonization Manager with Maelstrom Research Group at the Research Institute of McGill University Health Center. So that was a long introduction but very important that you have the context for our presenters today but now I have the privilege to passing it along to our presenters and I believe Dr. Rayna will be beginning. Great thanks very much Jennifer and thank you everyone for being here today. What I'm going to do is I'm going to give you a just a review of the CLSA and then share what we have in plan for the coming years or as well as for the follow-up three to follow-up four and beyond what we plan to do in the CLSA. Next slide please. Yeah next next slide. Tina Wilson from McGill and Susan Kirkland from Dalhousie University are the core principal investigators, co-leads of the CLSA and Lauren Griffith and Cynthia Ballian on the next slide are the co-PIs of the CLSA initiative. Next slide please. Just to remind all of you that CLSA is developed as a research platform and the idea behind CLSA is to provide researchers and policy makers a wealth of data that is relevant to aging process and aging Canadians. So the idea is to create a platform that provides evidence based information for decision-making that leads to better health and quality of life for Canadians. Next slide. These are some of our collaborating institutions right across the country. I won't go through all of them but they have all been important players in the CLSA right from the beginning and continue to be strong partners going forward. Next. Just so remind all of you that just to keep this terminology in mind Tracking Cohort which we call Tracking Cohort it is a 20,000 participants randomly selected from all 10 provinces and they only provide data by telephone interviews that last anywhere between 60 to 70 minutes and these telephone interviews are repeated every three years and then we call other other cohort comprehensive cohort which is a cohort of 30,000 people living within 25 to 50 kilometer radius of our data collection sites. Those are located in small cities, mid-sized cities and large cities and these individuals are followed through in-home interviews and then they are brought to our data collection sites to provide detailed assessments on physical measures as well as blood and urine samples. And when I throughout my presentation I will use the word tracking and comprehensive and that's what that looks like. Next slide please. Just to remind everybody and see there are many people who are online today who have been the users of the CLSA data. Exclusion criteria is what that their residents in three territories, persons living of federal first nation reserves, full-time members of the Canadian Armed Forces, individuals living in an institution and individuals who are not able to respond in English or French and any individuals at baseline who had a cognitive impairment or other cognitive impairment to not be able to provide consent to participate in this study in a longitudinal fashion. So these are some of the people who are not part of the CLSA sample. Next please. So this is this gives you a sense of the scope of the study. It goes from coast to coast mostly but not to Antarctica from St. John's Newfoundland to Halifax, Sherbrooke all the way to Victoria. That's where our data collection sites are the big green dots and the blue dots are where all our tracking participants come from. Next. Again as I mentioned that we have 50,000 people in the CLSA at baseline they were between the ages of 45 and 85. Tracking cohort on the left is 20,000 followed data provided by telephone interviews and here you can see that we launched study end of 2010 early 2011 and that data collection went over for almost three three and a half years and finished baseline finished in 2015 and then we started the next follow-up one in 2015. A follow-up two began in 2018 and and half of the sample was pre-pandemic and other half was in the middle of the pandemic and our follow-up three that has begun now started in 2021 and that relates both to tracking and comprehensive samples. In addition to collecting primary data from the participants directly both in the tracking and the comprehensive side we also with their consent obtain health card numbers from all the participants and I think we have 92% of the people who have given consent to do the linkage with the provincial health registries and as I mentioned before on the comprehensive side we also collect questionnaire that are common with the tracking questionnaire but in addition to that we do clinical and physical assessments plus blood and urine and blood and urine are almost provided by 94-95% of the participants in the CLSA and all these measures are repeated every three years including the collection of the biological samples and to remind that the CLSA is designed to continue till 2033 that's when our last follow-up will finish. Next slide please. Again just a reminder many of you have seen this before our questionnaire based and passive data collection in CLSA includes on the left side health information we have information on chronic disease and chronic disease symptoms, pain and general health, medication, supplement intake, women's health, self-reported health service use, oral health, preventive health that was only administered in baseline and we have reintroduced that which I'll describe later and you can see then we have post-traumatic disorder, injuries and consumer products, mobility this is how people move in their environment and then the lifestyle related questions and on the right side of the panel are our sociodermic demographic and psychosocial related questionnaires and you can see elder abuse was originally introduced in follow-up one adverse childhood experience was introduced in follow-up one as well and intimate partner violence data collection was part of the follow-up two both elder abuse sorry the follow-up one is no longer need to be administered because this was a historical information we were collecting and intimate partner violence was later to be only collected during the follow-up two. As I said we have health care numbers to do the administrative data linkages as well and it is planned and it's in progress right now. Next slide. In addition to the primary data collection we also have collaborated with the Canadian urban environment health research consortium that are creating contextual environmental data and we are at postal code level or dissemination level depending on what level of geography their data are available we are linking those data to each and every individual in the CLSA so far we have some of these indicators as part of the CLSA database as well as for some new ones that are coming down the pipeline. Next slide. In addition to the questionnaire or clinical assessment or or canoe data we have already multitudes of biomarkers and omics in the CLSA we have we do hematology at every cycle of the CLSA data collection we do biochemistry and in follow-up one we introduce high sensitivity troponin anti-pro BNP for heart failure IL-6 and TNL for inflammatory processes we did the genotyping using UK Biobank area and all baseline participants right now we are in process and looking at whole exon sequencing the negotiations are in progress and at baseline we also generated EWAS data epigenetics data on roughly 1480 individuals it says 1500 here that was our target but we ended up doing around 1480. We have also done with those data already available metabolomics analysis on the baseline 10,000 people and we are just beginning to do metabolomics on the remaining 20,000 and we will be doing metabolomics and follow-up one follow-up two and follow-up three blood samples as well and we are in progress to do some proteomics analysis we are looking at we are in discussions with a group who will do it and there are some funding geologists that we are looking to sort out in relation to these analyses next slide please these are some of the more detailed data collection physical assessments we do obviously height rate BMI bone density body composition erotic calcification blood pressure ECG CIMT pulmonary function vision and hearing that includes retinal imaging performance testing that is grip strength time up and go balance and 4 meter walk and as I mentioned blood and urine samples and and almost a 30 minute long battery of cognitive assessments and I will spend some more time as we are expanding this battery to include additional domains of cognitive assessments as well next slide please in the follow-up three we have new measures in the questionnaires we are adding a new measure of quality of life we are also going to be measuring because in the course the LSA we measure sleep but we are adding a supplement to that questionnaire that is going to measure the chronotype that means the timing when people sleep and how they sleep nutritional chronotype healthcare utilization a detailed module module on sexual health that will be administered via web family history of disease that's also going to be administered by web questionnaire on people who can complete it on web and subset of those who can't we will collect those data through telephone interviews the new physical assessments we are adding is the wearables actor graph and and tick watch to look at the people's mobility as well as to ascertain the physical activity chronotype vision contrast sensitivity measurements up to electronic motion capture that is a looking at gate and gate postures and biomechanics of people olfactory function and body temperature these are only in the comprehensive cohort as I mentioned already about the biochemistry and one of the new things we have added that is done on each data collection visit are some of the urine biomarkers as well using point of care device called clinic we are also reintroducing measures of elder abuse and preventive health behaviors next slide please there are some other platform enhancements that are happening this is a busy slide and I will take you through each one of these new introductions that are happening in the CLSA you can see in 2017 we started to collect information on the people who had deceased in the CLSA I'll describe that in a minute then in 2020 April of 2020 when the pandemic started we implemented a COVID-19 questionnaire study that went for almost 10 months and at the same time or in the middle of 2020 to middle of 2021 we launched a seroprevalence study as well and then there was a CHR funded study which started in 2020 to look at the long COVID related to brain health that's what we call the COVID-19 brain health study and in 2022 the people who are not able to people who have cognitive for other reasons have declined and can't provide data to us directly we have implemented a proxy questionnaire and again I'll give you a little bit more information about that in a few minutes another new to another new initiatives that we have started in the CLSA one call memory study again it started in 2022 and the other one is a healthy brain healthy aging initiative and both of those I will be introducing to you in a few minutes next slide please and as I mentioned already April 2020 to December 2020 we've introduced a web and telephone interviews that collected data weekly by weekly and monthly from almost 28,000 participants and all those there have been 13 or 14 publications that have come out of that data and and we also have a COVID dashboard on our website where you can go and look at some of these descriptive data as I mentioned the COVID-19 seroprevalence study was done under 19,000 people we collected blood through two mechanisms dried blood spots and venous blood samples it was a difficult study but we completed that and all the antibody results are being shared with the Canadian immunity task force for them to pool them with other data sets that also collected serum seroprevalence data from other populations and soon we will have a summary presentation of the basic descriptive data from the seroprevalence study on our website but some of the pool data are available on the CITF website as I mentioned that the COVID-19 brain health study was launched in summer 2021 and it is looking at impact recording COVID-19 on cognition and brain health of the people who actually tested positive in the CMSA versus people who didn't we send people for longitudinal MRIs and we also do additional cognitive assessments on phone of the people who go for MRI visits next slide please and the more recent and exciting initiative is what we call healthy brains healthy aging initiative this was funded by the western family foundation it's a 12 million dollar brain health initiative that is funded the follow up of around 6000 people follow up three and follow up four and hopefully if everything goes right they will be able to fund the subsequent waves of data collection for this initiative and this is to understand our to enhance our understanding of the age in brain and how people age in a healthy fashion from a brain point of view and others don't and what might be the precursors of that and it includes physical activities set into behavior and sleep type of measure as well and that's why some of the wearables have been introduced please continue so after 6000 people 2630 individuals will provide a brain MRI at follow up three and follow up four we are also collecting fecal samples from these individuals and we are adding an extra battery of cognition in these 2600 people and it's going to be specifically focused on master sample visual search paired associate learning rapid visual information processing and they will also be they will also provide data through mobility trackers and sleep trackers next slide please and the remaining of the 6000 that is 2600 plus 3370 3370 only provide fecal samples at home they return it to the data collection site and we have the funding funding to do the metagenomics on 6000 as well as metabolomics analysis on the on the stool samples on all the 6000 people next slide please in this case we are using a EEG based tool wearable tool called Muse that allows you to track sleep quality duration fragmentation efficiency looks at the architecture using EEG approved approved actograph that will go on the wrist and these are all going to be in not only administered in the healthy brain healthy aging study but all 30 000 participant except for the Muse Muse will only be done on the on the on the 2630 people who are participating in healthy brain healthy aging study next slide and as I mentioned earlier we have GPS and triaxial accelerometer devices tick watch an actograph which is worn on thigh and measures physical activity and sedentary behavior community mobility such as driving and this is going to be these are going to be done on all 30 000 or whatever is remaining I think on 26 000 comprehensive participants next as I mentioned decedent questionnaire was launched in 2017 it occurs three months after the participant's death or or after learning the participant is diseased if the exact date is unknown letter is sent to the alternate contact and file and the decedent interview takes approximately 20 minutes by phone or web next slide details surrounding death primary and secondary causes of death living arrangement prior to death cognitive and physical function at one month before death information about the main caregiver participants health care preferences and decisions quality of the participants death and how they died are collected as part of this interview next as I also mentioned that we do proxy questionnaire we have just started to do those participants over 70 years of age are asked to designate a proxy decision maker and a proxy information provider proxy decision may act on participants behalf if they are no longer able to make decisions for themselves both their participation so for example power of attorney and the proxy information provider answers interview questions on participants behalf and this tends to be someone who knows the participants well and participants may change proxy decision maker or proxy information provider anytime during the study if they are capable to do so next slide a proxy information provider answer questions through telephone interviews and we try to capture as much data as possible that the participant would have responded to themselves but there are some modules that are not relevant through proxy so we don't collect those and this will be done going forward three and follow up four as well and and subsequent rates next slide this is what we call a memory study it's actually a clsa dementia ascertainment study it is funded by public health agent agencies and hence dementia surveillance program ideas to look at undiagnosed dementia in canada we are developing algorithm to identify dementia cases using clsa data and then we want to validate this algorithm with clinical diagnosis and then the plan is to link the clsa data with provincial healthcare databases to see how these two databases ascertain dementia cases because through the healthcare databases it's estimated 30 to 40 percent of the people don't have diagnosis of dementia so these these databases underestimate and we are trying to provide a complementary data for dementia in the country and we're also doing analysis of known and emerging risk factors associated with dementia and we have done a systematic review we will map the results of the systematic review on to the clsa data to see what is being measured and where the gaps are and in the future we might consider adding those risk factors to the clsa platform next slide please and algorithm is based on 600 participants with a range of cognitive ability they'd go through a one-hour medical assessment with the study clinician it looks at medical history and brief cognitive test and your cognitive examination identify a family member or friend for a 20-minute telephone interview to get their perspective about the person's cognitive status next oh that's all i have to say and these are our researchers across the country who are supporting the clsa in wide variety of fashion and the majority of these people have been with the clsa since 2001 and we continue to add new expertise to our team as our range of activities widen now matilda will take over and describe how the data access works and what we have available and what what you can do to access these data as they emerge over the coming years matilda yeah hello everyone sorry i'm we have a technical problem i'm my camera is not working so and excuse my voice because i've been sick for the last two days i'll try my best to go over the so for the data availability i will go over the data that are currently available for data access requests and i will highlight those that are have been added recently or will be added soon so for the course lsa data we do have questionnaire data physical assessments blood biomarkers genomics epigenetics and metabolomics so for questionnaire data there are available for requests for baseline follow-up one and recently for follow-up two for physical assessment they're available for baseline and follow-up one and we expect to have those available for follow-up two next summer for hematology we do have those for baseline and follow-up one but for chemistry we do have it for baseline but we will have the follow-up one biochemistry data released next week so this will is coming soon and for follow-up two for blood biomarkers we still don't have a definite date for release and genomics epigenetics and metabolomics there are all currently available for baseline next slide please yeah so i'll go over a questionnaire data bit in details because we have regrouped many variable modules under this questionnaire data so what it includes under questionnaire data we do have social demographics lifestyle and behavior labor force physical health psychological health social health and medications and cognitions so they're all under questionnaire data and a checklist they're all available for baseline for follow-up one they are all available except for medications which we expect to have them by march 2023 for follow-up two we have released most of the variable modules under questionnaire data except for cognition and medications so cognition we expect to have those in summer 2023 and medications still to be determined i will highlight the new measures we have for for follow-up two here under physical health and psychological health so for physical health we have weight perception resilience in scale aortic vasthenosis and those are available only for comprehensive cohort and for the psychological health we do have generalized anxiety disorder positive mental health those two are available for both tracking and comprehensive cohort and we have the intimate partner violence which is only available for comprehensive cohort and next piece here just an overview for that about the cognition measures so what has been available for baseline and follow-up one and definitely you will have all this information on the website as well as in the data availability table next please yeah so for physical assessments modules so here this it lists all the physical assessments that were performed for the CSA participants at at the DCS visits so and this also includes the list of the images outcome data so it's also like whatever outcome data from images like ecg bone density dexa are all the data are listed here so that yeah so that's it for physical and those are available for baseline and follow-up one uh here this provides an overview of the core biomarkers at baseline and follow-up one so as you can see hematology variables are available almost all for baseline and follow-up one while chemistry almost all except two that are only available at follow-up one and other two at baseline here the second column the end represents the number of participants at baseline and as i mentioned before genetics epigenetic metabolomics are only available at baseline and this is the whole list i mean is available in the data availability check data table uh we are other than the core clsa data so we have linked data and this is environmental indicators as already presented so here we we did link can you and health canada data sets with clsa so those are available at baseline and we will be releasing the follow-up one environmental indicators also next week so those will be become available for data request too for follow-up two data we still don't have a date for release next please okay yeah and definitely images and draw data are available for data request so we have simt dexa ecg retinal scans pyrometry tonometry and row cognition so those data are available for request if you want to request these data you need to provide detailed justification explaining how these data are will help to actually propose objectives and how they will be analyzed so it requires a bit further explanation as compared to the regular data and definitely you need to have the experience and resources to work with these data and uh this involves additional costs and it would take more more time to list those data due to the extensive work needed to copy and to prepare this data so those are available currently for baseline and follow-up one and still to be determined for follow-up two next year yeah and we have two uh COVID-19 studies where we can request data from so those uh the COVID-19 questionnaire study as well as the COVID-19 seroprevalence study which we recently released i won't go over into details already permanent represented those so the that's are available for request uh and we have added a new tab uh to our data checklist which is mortality data and this includes the participant status as well as the as the decedent questionnaire data so for participant status it's uh we can't say it's the vital and withdrawal status if a participant is alive dead or withdrew and the decedent questionnaire data it's more uh as presented it's uh detail surrounding death so those information now they're available for request what have we have released already is information collected by march 2022 so this will we will keep updating those data so probably it we will update once or twice per year and we'll have more uh like every year we'll have more updated information okay so that was for data availability and now i'll go over the data access um so i will first go over um the approved applications we have so far so each bar here represents the number of total approved application per year and the blue section represents um the 20 applications so so far we have almost uh 500 or more applications that were approved in next yeah so since yeah we have 500 applications approved since 2014 next please this is a table also presenting the same information and which we can see we have 318 researcher application approved as well as 183 training applications so almost like one-third of the applications are training applications okay so now for up to apply for data access there's several steps here so step one would be request an account step two login and start an application step three complete the form and step four submit your application so i'll go over step one next please so step one uh you first request an account so the primary applicant should email the access email to request a magnolia user account and provide by providing full name institutional email and position title and institution so and it usually takes two to three days to who get to receive the login information uh if it's a trainee application uh that's that's a provider which is the primary applicant on behalf of the trainee also needs to email the access email and request a magnolia user account for the trainee by providing their name institutional email and program so once you have your login credentials you need to log in and start an application here this is how the magnolia uh page looks like so you need to enter your username and passwords and your starter application just i want to highlight for trainee application it should be the trainee who should sign in and once they sign in next slide please um well so once they sign in there this is what what looks like it's a page with instructions and notes to the applicant so uh the trainee here there's an ad button on the below uh uh so where's the blue arrow so the trainee must click the ad button and start the application so this is very important because uh if the supervisor initiates the application the trainee cannot be added so it should be the trainee who initiates the project in magnolia and this we we do this because we want to ensure that the trainee uh provided the learning opportunity to write their own proposals so after it will be step three which is complete the form so there's four tabs here uh instructions part one part two and part three uh so i always insist a lot i mean you need to read carefully the instructions written here and this is there's uh it also has a links to different resources on the clsa website so the more you know clsa the chances your application will be accepted are higher so uh we always it's never enough i mean so uh after reading the instructions and understanding clsa well there's part one which is the app it includes information different tabs the applicant project team timeline description and scientific review and ethics and if there's part two which is the data checklist you select the data here in part two and there's part three about biosamples but it's not activated yet so under part one and there is the applicant tab so here the applicant information is entered here and there is a section on the bottom for the trainee information which i i show here so it's here so as i said the supervisor is the main applicant and the trainee information would go here so uh and please make sure you specify the the few waiver on the bottom two next tab would be it's the project team so here just make sure they include all the project team members here uh and that multiple can be added here uh we are for the description tab so here it says the proposal per se so here where you write your proposal so there is a project title keywords lay summary background study objectives study design and data analysis so i want to highlight some points here like make sure you write the lay summary in the lay language make sure the objectives are clear and concise make sure you the use of requested CLSA data is described here and that you provided enough information to assess visibility so now i will go to part two the application form so part two as i said is the data checklist so there's the first tab is the notes so here and it there's a link for the CLSA data availability table i include your screenshot it's a PDF document that we always update with what is currently available for data requests so make sure you consult this before you select the data and there's a second tab here which is that we need to choose the cohort so we either choose tracking or comprehensive or both just please note that there are no physical assessment or medications and biomarker data for tracking cohort so if your project depends on those data you need not to select tracking cohort and there's a question on the bottom here with i mean if you need to specify if your project is related to a previous approved CLSA project and if this is the case you provide the number of that project but make sure if this happens describe in the proposal what are you adding to the previous approved project yeah and here is for the core CLSA data tab so make sure you select only the modules needed for your project so just like whatever you need you just select those the way i mean the modules as well as the waves so if you only need baseline you only select baseline if you only need questionnaire data you only select questionnaire data and make sure they are described in your proposal whatever you select here just i want to highlight again that cognition and medications data are included in the questionnaire data module so those are here if you select questionnaire data you'll get those you'll get all and there's yeah and there is i mean here the images and raw data i will select only images if they're needed so because i mean we do get a lot of those selecting images but the only they need is the outcome the output data so that are available in the physical assessment module so if you select images and you need images you need to describe how they will be achieved and they will use to achieve proposal objectives and how they will be analyzed the definitely involved additional costs and step four would be submit your application so here is important even if it's a trainee application it's the primary applicant who needs to submit the application of the trainee so although the trainee will fill out all the application the primary applicants and this is to ensure that they had they he she were able to review the proposal before they submit and applications must must be received by 5 p.m eastern time on the submission deadline so here are our 2023 application deadlines so we have january 18 april 12 july 12 and october 4 go over the data access timeline in brief so after you submit there's the review process which takes around 10 to 12 weeks and after the review process there's the agreement phase the agreement phase i mean we don't have control over this phase it might take up to 12 weeks depending on the institution and after there will be a data release so the data release usually takes five to seven days except if there's images i mean it will take much longer and yeah so you need to plan that it's of a since after submission it might take around six months to receive the data so the review process here includes administrative review to ensure that the application is complete visibility review to ensure that the data are available requested data are available and we have the data and sample access committee review which is an independent committee to provide scientific review and recommendations to the CELSA executive committee and the CELSA executive committee would have the final decision the review outcomes are approved include approved minor revision which would provide the applicant seven days to resubmit major revision 21 days to resubmit and not approved here is our data our data and sample access committee the currently we have the chair and 15 other members from different academic Canadian institutions as well as CELSA and CHR representatives okay i will go over and brief what are the main reasons like why we send back the application and this is important for you because i mean if we send back the application definitely it will delay the process and if i mean you can avoid this that will definitely help in approving more and more applications so main reasons for minor revisions usually writing delay summary in a language that is not suitable for the general public so we send back the application so they can rewrite the summary and this is important because we post those summary on our website so it's important to ensure that it are suitable for the general public second reason is selecting a cohort that is does not include the data needed for the proposed project so they like i said before like selecting the tracking cohort for example and the project depends on physical assessment let's say or whatever but cohort wants a tracking cohort to want and don't include this information so we send it back to remove the tracking for her and selecting data modules are not described in their proposal so yeah like including can you data or COVID-19 selecting those in the data checklist but there are no mention about those data in their proposal so do we either we send back they either need to justify their request or they need to remove those data from the data checklist requesting images although only images output data are needed and this is we send back and it just mean we tell them that it's a physical they're including the physical assessment module and they need to remove their images so main reasons for major revisions are and this is 21 days usually um research objectives are not clear and concise enough and the use of requested data is not adequately described and proposed methods are not clearly described so we provide we ask them to rewrite those and we are for rejection we do reject some of the applications although few but mainly due because a requested data are not available at that time of submission uh or they're tailored to provide the level of detail sufficient to assess the study visibility or once we send back for requested revisions they don't apply those requested revisions so we have to reject it yeah so finally for the fees for the alphanumeric data it is $3,000 for researchers based in canada and it is $5,000 for researchers based at institutions outside canada and the graduate student or postdocs can request a fee waiver if they're using the data only for their pieces or for the fellowship project um it is one fee waiver per program per applicant um fee waivers only apply to trainees enrolled at a canadian institution or supported by a canadian funds working outside canada um and definitely images and complex data would require additional fees and the fee waiver does not apply to those yeah so that's it if you have any questions you can always email us at access at clsa-asv.ca for data and access inquiries great so i think that wraps up matilda thank you very much i find your presentation is always very detailed and i'm sure everyone here will um be able to use what you've said to improve their applications and and uh likelihood of success um pommender was very uh again savvy at answering a lot of the questions in the chat so hopefully um most of you have been following along in the chat box um she's posted answers to most questions i think i don't actually um think there's any more of standing so if you do have any more um questions please write them in the q and a box um i see one did just come in about link with administrative data the question is does it mean linkage with inpatient outpatients or emergency room databases yes so it means basically the physician billing data hospitalization data on nackers national ambulatory care wherever it is available or variation of that and other potentially provincial databases that might be common to all provinces or available at some provinces such as homecare or or um interi type of data and just to uh just to say that we are in negotiation with provinces and we are still at the stage of signing agreements when it will happen it's hard to know we hope it happens in the next 12 to 24 months but you never know because of all the privacy and confidentiality legislations that happen in provinces and uh and just to add to one question from susan stock in relation to the labor force data we also have data in relation to pre-retirement and retirement and you can go to our website and all the questionnaires are there and you can see through modules what's included and what's not included um and what about maybe uh either of you could answer the question do you suggest we submit our proposals to a local rev in parallel with the clsa or wait until we get approval um i suggest you put it in as soon as you submit it to the clsa because it'll speed up the process for you getting data once all the agreements have been signed but it varies depending on how long it takes from your institution to get approval done um just a reminder it's more it's helpful if you put questions in the q&a box so that we don't have to bondage her both the q&a and the chat our data we have a modified consent i think it goes 15 years prior to the clsa started and and and all going forward so it's retrospective as a perspective linkage at least plan we'll see whether provinces will agree with that but that's what we are planning to do bottom line is it doesn't matter what we have asked in the consent and what people have signed on their consent it's at the end of the day it is to be determined by the data custodians and privacy commissioners at each province what they will allow and i also just want to draw to everyone's attention in case you haven't uh been monitoring the chat any questions you might have about content of clsa questionnaires or modules um our questionnaires from follow-up um all the way up to follow-up free are available on the clsa website as well as lots of um resources and tools that you can see what's included in the various modules um and of course you can also send an email to our esteemed data access officer to help as well um so we have time for a couple more questions one another one is if chemistry for follow-up one is being released next week should we expect the full release of biomarkers such as t and f um alpha as well yes yes i already typed in all right great there was a question about uh sexuality what are we collecting under such sexual health i don't know if you responded but i did i actually posted a response that the questions are actually going to be part of a web-based questionnaire that will be administering after our of all our standard um interviews at either the data collections like for um on caddy telephone calls and they relate to um importance of healthy sexuality as well as satisfaction with sexual partners and so that questionnaire isn't posted yet but if you want any more information you can get in touch with us um all right well we're wrapping we're coming to the end and i don't see any more active questions in our q and a um so perhaps i will just go on with the uh tail end of what we need to say in terms of our clothing um so again thank you this is always uh we do this webinar every year or two and we always find the participation in questions um outstanding um so thank you to our moder our our presenters as well as participants for asking all your questions um i'd like to remind everyone that the next deadline for data access applications is january 18th of 2023 but you can visit our CLSA website under data access to review what data will be available as well as the details about the application process and now that you've had a refresher in uh our application process we look forward to your applications i'd also like to remind everyone to complete their anonymous survey upon exiting the zoom session today um that will come up automatically the next CLSA web webinar will be presented in november by dr embram satya uh and it will be based on his publication prevalent incidents and characteristics of chronic cough among adults from the CLSA and registrations for that CLSA webinar will be posted on our website if it's not already posted now it will be posted very soon and then if you're a if you're a tweeter a reminder that CLSA promotes this webinar series using the hashtag CLSA webinar and we invite you to follow us on twitter at at clsa underscore elcb so that brings us to one o'clock right on the dots so thank you again to everyone if there if you had any questions that weren't responded to we will follow up via email with the responses to those questions so enjoy the rest of the day and happy halloween