Idiopathic polyneuropathy, pain and Palmitoylethanolamide (PeaPure, Normast)





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Published on Sep 21, 2010

Treatment of a chronic painful state in an old lady, due to a chronic axonal neuropathy by palmitoylethanolamide, PEA, with good result, pain decreased from score 8 to 2-3 on the numeric rating scale for pain. PEA is world wide available via the internet in the purest form as PeaPure.

As the 90-year old patient was totally reluctant to take anagesics such as amitriptyline and pregabaline, due to side effect issues, we started with administrating Palmitoylethanolamide (PEA), an endogenous fatty acid amide analogue of the endocannabinoid anandamide. Dose selected, amongst other sources based on a clinical trial in sciatic neuropathic pain, was 1200 mg daily.

In 2 weeks time het NRS pain score decreased from 9 to 5. On the DN-4 after 2 weeks she scored 4, a reduction of 33%. After week 3 the pain was reduced to 2-3, and in the next weeks (weeks 3-6) the score remained stable on 2-3. No side effects were seen.

PeaPure is produced in the Netherlands and Normast in Italy.

In our clinic we continously search for new and better drugs and treatments for patients suffering from neuropathic pain. As many patients suffering from neuropathic pain are elderly people, with co-morbidity, often also facing cardiovascular problems, drugs like amitriptyline are relative contraindicated. Moreover, the sedative side effects are a big problem for these frail and mostly gait-unstable patients with polyneuropathy. Pain in the elderly is distinctly different from pain experienced by younger individuals. And thus pain in elderly needs individualized treatment. Considering side effect profiles is an important aspect of such a treatment.

Example of analgesic treatments with a low side effect profile are palmitoylethalonamide (PEA), brandname PeaPure or Normast, and alpha-lipoic acid. Especially the absence of sedative side effects is important.

Website on PEA: www.palmitoylethanolamide4pain.com

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