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Uploaded on Feb 1, 2012
Collagens are the most abundant protein in animals forming the extracellular matrix involved in the adhesion and migration as well as the transduction of signals that regulates cell growth and differentiation. One of such signal transduction pathway could be envisaged in the complex with cell surface protein integrins. Triple-helical fragments of collagen at the middle sequence motif of GFOGER (O= hydroxyproline) are bound with the extracellular I-domain of integrin a2b1 coordinated with a metal at the interface. The allosteric change of the integrin causes the structural change of the cytoplasmic tail leading to the outside-in signaling (1DZI.pdb; ref. Emsley et al. Cell v101, p47).