 The study investigates the association between genetic variants in the iron pathway and sudden sensorineural hearing loss, SSNHL. Among the investigated genetic variants, SLC40A18GG homozygotes and SOD216VV genotype were found to be associated with increased SSNHL risk. Additionally, Line A1 methylation was inversely related with hearing loss score assessed as pure tone average, PTA. Principal component analysis, PCA, yielded PC1, which was associated with moderate severe profound HL and severe profound HL, highlighting the potential value of recognizing genetic and epigenetic biomarkers in SSNHL for pharmacogenomic database drug design. This article was authored by Veronica Tisato, Alessandro Castiglione, Andrea Ceauber, and others.