 The naturalness of severe acute respiratory syndrome coronavirus 2 infections, SARS-CoV-2, appears to impact the respiratory system and lungs, however, the etiology of many cases exhibited several various features of the disease. This review gathered contemporary information from PubMed, Scopus, and ScienceDirect databases regarding possible effects of the virus in generating reactive oxygen species and causing oxidative stress. The literature suggests that COVID-19 is associated with reactive oxygen species and its comorbidities mostly joined with oxidative stress including hypertension, cardiovascular, thrombosis, obesity, and diabetes besides of chronic obstructive pulmonary disease and asthma. This article was authored by Hardy Rafatbaki, Helgaard Ali M. Farag, Abdul Hamid, H.L. Bilbezi, and others.