 The study found that certain gene variants were associated with increased risk of developing central adiposity in both men and women. Specifically, men who had variant versions of the gene for the vitamin D receptor, VDR, were more likely to have elevated central adiposity, while women who had variant versions of the gene for the megalin, LRP2, were less likely to develop elevated central adiposity. Additionally, men with variant versions of the VDR gene were also more likely to experience significant increases in central adiposity over time, while women with variant versions of the LRP2 gene were less likely to do so. These findings suggest that variations in these genes may be involved in the development of central adiposity, and further research is needed to determine how these genetic factors influence body fat distribution.