 We investigated the Hepatoprotective Effect of Celebenin, SLB, to ischemia reperfusion, IR, rat model by evaluating the histological expression of Fars-Fars-L, HMGB1 and CD45 markers and SLB pharmacokinetics. We found that SLB reduced the expression of these markers in liver tissue under IR conditions and improved its pharmacokinetic properties in ischemic animals. The results suggest that SLB has a protective effect on the liver during surgery. This article was authored by Alexandra Kateserusha, Georgia Valsami, Nikolaos Kostomitsopoulos, and others.