 This study aimed to investigate the knowledge and attitudes towards human papillomavirus, HPV, vaccines among female high school students in Jimma Town, Ethiopia. The results showed that only half of the respondents had good knowledge and nearly one-third had positive attitudes towards HPV vaccination. The predictors of knowledge included parents' educational status, school minimedia participation, smartphone ownership, availability of radio or TV at home, and social media information. All concerned bodies should work together to enhance the knowledge and attitudes of female students towards HPV vaccination. This article was authored by Tzegor Biazin, Jennifer Yilma, Ainalyn Yetwell, and others.