 We have developed a serology test platform that can identify individuals who have been exposed to certain viruses. This platform consists of a pair of engineered cells, one which expresses a virus envelope protein and another which recognizes the FC region of an antibody. When these cells come together, they form an immune synapse, which is then used to detect the presence of antibodies specific to the virus. This test can be used to quickly and accurately determine if someone has been exposed to a particular virus. This article was authored by Marvin Asimidali, Juan Arredondo, Elyse Buzer, and others.