 The global prevalence of severe acute malnutrition, SAM, is estimated to be greater than one-third of all deaths in children under five years old, and approximately 54 percent of deaths in developing countries. The minimum international standard for the management of SAM is a cure rate of at least 75 percent and a mortality rate less than 10 percent. This study was conducted to determine treatment outcomes and associated factors among children aged one to five years who were hospitalized with SAM in LASA and Gulu Regional Referral Hospital, GRH, in 2017. Retrospectively, medical records from both hospitals were reviewed, and data was analyzed using SPSS version 16. The case fatality rate, CFR, was 12.6 percent in GRH and 9.5 percent in LASA. The average length of stay, loss, was 14.69 days in GRH and 14.10 days in LASA. Statistical significance was found between HIF status, blood transfusion, type of SAM, treatment provision at admission, antibiotics, mid. This article was authored by E. Muangusi, J. Eros Obwa, and Abamba, and others. We are article.tv, links in the description below.