 The study evaluates the efficacy of hydroxyl tyrosol, a natural antioxidant derived from olive oil, in local treatment of inflammatory colitis. Hydroxyl tyrosol has been shown to have anti-inflammatory effects and no toxicity in previous studies. In this study, rats with trinitrobenzene sulfonic acid-induced colitis were treated with pectin-alginate mixture, olive oil, or a combination of both, including hydroxyl tyrosol. The results showed that the combination of hydroxyl tyrosol, pectin-alginate, and olive oil was effective in reducing inflammatory infiltration in TNBS-induced colitis. This article was authored by Evolts, Obamudas, George Regas Gatiers, and others.