 Pseudomonas originosa is a grand negative opportunistic pathogen that infects patients with various conditions including cystic fibrosis, burned wounds, immunodeficiency, copped, cancer and severe infection requiring ventilation. It is also used as a model bacterium for all biological areas. Research has focused on understanding its pathogenesis, host pathogen interaction and drug resistance mechanisms. Technologic advances have been employed to improve our understanding of p-originosa pathogenesis and host defense. Despite this progress, much remains unknown about interactions between p-originosa and host immune responses, necessitating the development of new theoretical and practical platforms to screen and develop mechanism-tested novel drugs to treat intractable infections caused by multidrug resistance strains. The review comprehensively covers p-originosa biophysical traits, behaviors, virulence factors, invasive regulators, and host defense patterns against its infection, providing new directions for future investigation and alternative therapeutics. This article was authored by Xu Gangqin, Wen Xiao, Chuan Mingzhu and others. We are article.tv, links in the description below.