 We're here at the nanotechnology conference and hi. So who are you? Hi myself Sahit Yakumar. I Am from Italian Institute of Technology. I am in affiliation to University of Genoa in the in the group of Dr. Teresa Pellegrino So So what do you present here? So I've written means basically we work on clustering of iron oxon nanocubes for magnetic hypothermia Therapy and if you see at the basically the magnetic hypothermia is a method of killing cancer at the elevators of 40 to 42 degrees where the cancer cells are basically Sensitive and this method is FDA approval and most of them are in clinical use for glioblastoma or some kind of solid tumors What however this magnetic nanoparticles which can produce heat for killing cancer in the Which are available in the magnet in the market are not really performing good with respect to that of cubic shape iron oxon nanocubes which we published in 2014 a Paper that explaining the cubic shape nanoparticles are far better than the spherical one Actually, they are different factors which decides the performance of magnetic nanoparticles in heating especially coming to the magnet Applied magnetic fields and also the properties like size shape and composition and importantly also we have to consider the arrangement of nanoparticles So actually I mean it was it's a state of art like Magnetism bacteria having a linear change iron oxon nanocubes was studied that the performs far better than the isolated states But we tried to fabricate this kind of linear structures for using the same building blocks here To enhance the heating performance Because as I said like arrangement improves also dictates the performance of magnetic nanoparticles in heating So initially we started this study pursuing this iron oxon and a few the same building blocks which are less interactive using a commercially available polymer By using a micro emulsion and slow solvent evaporation technology We can see here. These are hydrophobic and this is an amphipilic polymer We can modulate the shapes from the single structure to the elongated structures to the three-dimensional structures Using the same polymer by changing the amount of polymer here if you go if you go into the structures of magnetic properties with respect to the isolated structures that The one which is elongated like the sign like morphologies are Performing having the higher magnetic properties than those of the single one and the one Structures which are three-dimensional which are having more than four nanoparticles this is because When the particles are in elongated state because of when they are in elongated shape You can see they have a dipolar interaction and the anisotropy increases and because of that reason this Magnetic momentum behaves in a elongated entity and responds quickly to the magnet That's the reason why the elongated structures behave far better than the isolated one and the three-dimensional structures So what does it mean? Can you detect them or detecting things or you affecting something? What are you doing exactly because I said like in the in the beginning this magnetic nanoparticles have the properties of producing heat with respect in response to the Alternating magnetic fields that we apply externally when we inject these particles into the cancer cells when we applied this magnetic fields these Because of the flip of the nanoparticles inside the cancer cells or the magnetic momentum spin They dissipates heat and then they creates a pop process to the cancer cells and kills the cancer cells This is the basic concept of So are you able to to do this in real people or is it then in a way in the lab? Actually, this procedure was actually approved by FDA for glioblastomates in practice, but still there is a lot of room to explore Explore the methodologies to improve the heating performance of nanoparticles even at the low doses because the the current the clinical Applications lead needs the injection of a lot of doses of the nanoparticles into the target site Which is not really recommended because that is associated with toxicity issues So we are finding a way to reduce the dose and the strategies to reduce the dose and improve the properties as well. So this hypothermia Basically, are you burning the cancer out exactly you making something some parts of it too hot and it just disappears This appears yes, so this is what we are killing the cancer cells We had the elevated temperatures of 40 to 42 degrees because beyond that even the healthy tissue could undergo necrosis, which is not really recommended. How do you? How do you heat it up in there? Okay? So there are plenty of words in the in the literature saying that we can modify these nanoparticles With some target ligands which is specific to the specific cancer and they can reach directly to the cancer cells Targeting the specific cancer cells and they internalize to the cancer cells and they can dissipate heat when you apply the magnetic From inside the cell or even the extracellular environment covering the cancer cells. So your work is to do all this What is this? This is your paper. What do you call poster? Yeah, this is our poster. Of course, this was published in ACS It was developed by Dina Nicholas. And of course I was also involved in this project As an order and I am presenting this as a poster in this conference. Yes, and what's next? We are going we are trying to go for in vitro and in vivo studies on this and I want we want to do some kind of improvements in this studies because since these particles are less interactive We want to also extend this study for high interactive high highly performing iron oxen and a cubes as well. Yes so Is the vision here that this this cells potentially some types of cancer? What does it do? So we would say there is a lot of way to go and a lot of things because you know that when we go to in vivo Experiments, we have to consider various kind of parameters because especially the sale coming to the safety point of view of the patient as well I would say yes This is potential way because if you are combining with studies saying if you are combining this therapy with the chemotherapy So effective at least for the in vivo In vitro point of view next stage there is immense immense amount of work to be done To reach the potentiality to the in vivo and the clinical level And how fast can it get? This is a good question But the point is there are a lot of parameters one we have to adjust in this point of view Especially applying The magnetic fields because we have we should have a proper material that could response even at the biological limit of magnetic response Do you have it this material are you looking for it? There are some materials which are performing but there is not clinically approved yet This kind of high performing, but there's a lot of people working on in this direction as well Yes, and you are we are also going to do it. Yes, even my my boss, right? She's like there is a peligrino. She's intensively working on this kind of area of studies. Yes