 This study demonstrated a novel biomaterial-based approach to produce highly active extracellular vesicles from endothelial progenitor cells, epices. The researchers used silicate ions derived from bioactive silicate ceramics to stimulate epices, resulting in increased levels of mere 126a, 3p and other angiogenic factors. These factors were found to be responsible for the improved vascularization seen in mice treated with these engineered extracellular vesicles. This suggests that this method could potentially be used to treat myocardial infarctions. This article was authored by Bin Yu, He Kaili, Zhou Anbin Zhong, and others.