 The death-cap mushroom, ammonite aphaloids, is one of the deadliest species of mushrooms on earth, responsible for over 90% of mushroom-related fatalities. Its primary toxin, amanotin, is highly potent and has no known antidote. In this study, researchers discovered that a protein called STT3B is essential for the toxin's activity, and that a compound called indocyanin-green, ICG, can be used as a specific antidote. Using a combination of genetic screens, computational analysis, and in vivo testing, they found that ICG blocks the toxin from binding to cells and prevents cell death. This discovery could lead to the development of a new type of antidote for people who accidentally consume the mushroom. This article was authored by Bei Wang, Arabella H.W.A.N., Yushu, and others.