 Photodynamic therapy, PDT, is a treatment for non-melanoma skin cancers that involves applying a photosensitizer, irradiating with light, and oxygen to destroy damaged cells while leaving normal skin intact. In dull, three-acetic acid reduces incubation time, avoids photo-protection, and causes minimal pain. Cyclic PDT delays actinic keratosis appearance and reduces new AKS. PDT is also effective in photo-rejuvenation, improving skin texture, wrinkles, and firmness. Clinicians should stay updated on PDT efficacy and safety for expanding applications. This article was authored by Kwanoo Yen and Amor Kashmown.