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The Huntingtin Interactome

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Published on Jul 11, 2012

Obtaining a clear picture of the proteins that interact with the Huntingtin protein will provide clues for the development of Huntington's disease therapies. In this study, William Yang and colleagues used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin in both Huntington's disease and wildtype mouse brains. Using Weighted Gene Correlation Network Analysis, they unveil a network of Htt-interacting protein modules that provide insight into distinct aspects of Huntingtin biology.
For more details, see Shirasaki et al., Neuron 75(1).

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