Rating is available when the video has been rented.
This feature is not available right now. Please try again later.
Published on Jul 11, 2012
Obtaining a clear picture of the proteins that interact with the Huntingtin protein will provide clues for the development of Huntington's disease therapies. In this study, William Yang and colleagues used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin in both Huntington's disease and wildtype mouse brains. Using Weighted Gene Correlation Network Analysis, they unveil a network of Htt-interacting protein modules that provide insight into distinct aspects of Huntingtin biology. For more details, see Shirasaki et al., Neuron 75(1).