 This systematic review and meta-analysis found that food insecurity is associated with an increased risk of multi-morbidity in adults. Three out of four studies included in the analysis reported an increased likelihood of multi-morbidity among those who are food insecure. Additionally, three out of four studies also reported an increased likelihood of multi-morbidity among those with lower socioeconomic status. These findings suggest that food insecurity may contribute to multi-morbidity by limiting access to healthy food choices and preventing individuals from consuming adequate amounts of nutrients. This article was authored by Maria Cantolafti, Konstantinos Giannico, and Stavri Chrysostoma.